Trump’s provoked Sino-US trade war was directly aimed at forcing China to further open its market to the United States with a serious imbalance between China and the United States. The deep-rooted purpose was to try to re-enact the US-Japan trade war in the 1980s to curb China’s renaissance, while in November. The US Congress voted before the midterm elections. The responsibility for serious imbalances in Sino-US trade is not in China, mainly due to the status of the US dollar international reserve currency, the low savings model of US over-consumption, the division of labor in the global value chain, and the US high-tech export restrictions on China. The Sino-US trade war may not be fully launched in the short term, but if the two sides are not properly managed, it is likely to escalate. If the Sino-US trade war is fully upgraded, it will have a negative impact on China’s high-end manufacturing development and economic growth, but it will also increase the cost of living for the American people, push up inflation, restrict consumption, and cast a shadow over the global economic recovery. China’s response options include: accurately countering US agricultural products, automobiles, and airplanes to promote peace; uniting with other countries and regions such as the European Union, Asia, and Africa to expand the “Belt and Road”; exchange rate depreciation; selling US debt; limiting US corporate investment Develop a new national strategy. External hegemony is an extension of internal strength. The Sino-US trade war, our best response is to push for a new round of reform and opening up with greater determination and greater courage. To conclude, the Sino-US trade war has opened the prelude to the change of global leadership. If we can successfully promote a new round of reform and opening up, it will lay the foundation for the future of the global manufacturing industry.